The first is Paul Pritchard, who was a North Wales based climber until an accident climbing a sea stack in Tasmania left him hemiplegic. Not a man to take such things lying down he has continued his life as an adventurer. His latest trip is to ride a recumbent tricycle 1100 km across the Roof of the World from Tibet to Kathmandu to raise awareness for blind Tibetan orphans. Many Buddhists believe that being born blind is karmic punishment for bad deeds in a former life, so blind kids are driven from their family homes and made to fend for themselves. Braille without borders is a small charity that helps these children punishment
Paul is one of the most inspirational people I have ever met, both before and after his accident. If you are feeling down then his courage and spirit should help to give a bit of perspective.
And on a similar note, check this guy out. Truly inspirational